- 学历/学位: 研究生学历/博士学位
- 研究方向:
生物合成工程
- 邮箱: yjhan@ipe.ac.cn
- 地址: 北京市海淀区中关村北二街1号
- 邮编: 100190
- 课题组网站:
简历介绍
韩业君，研究员、博士生导师。2008年, 获中国科研实验室过程工程研究所生物化工专业博士学位。2008年至2013年，先后在美国伊利诺伊大学-香槟分校、北卡州立大学，从事微生物和生物合成方面的博士后研究。2013年，进入中科院过程工程研究所、生物药制备与递送全国重点实验室工作。主要从事酶催化和合成生物学方面的基础理论和工程技术开发研究，涉及微生物基因工程、酶工程、微生物发酵、工程菌构建、生物质的生物降解和转化等领域。在国内外学术期刊上发表SCI 收录论文60余篇, 担任Applied and Environmental Microbiology等学术期刊编委，取得美国和PCT专利3件。2017年，获第三届“闵恩泽能源化工奖”杰出贡献奖。
代表论著
1. Xin Pu, Caihong Weng, Yong Li, Biao Geng, Haiqian Yang, Xiaowei Peng, Yejun Han* Engineering mxotrophy in the chemolithoautotrophic Cupriavidus necator through hydrogenase induction. ACS Synthetic Biology. 2026,15(2), 773–788.
2. Haiqian Yang#, Wei Liu#, Jiwei Niu, Biao Geng, Yingxiang Sun*, Yejun Han* Integrated metagenomic–metabolomic insights into plant–microbe interactions mediated by Bacillus volatile compounds. Applied and Environmental Microbiology. 2026,92(4), http://doi.org/10.1128/aem.02523-25.
3. Caihong Weng, Xin Pu, Ruohao Tang, Yejun Han*. Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator. SCIENCE CHINA Life Sciences. 2025. http://doi.org/10.1007/s11427-024-2864-5.
4. Haiqian Yang, Jie Gao, Xiaowei Peng, Yejun Han*. Application of synthetic biology strategies to promote biosynthesis of fatty acids and their derivatives. Advances in Applied Microbiology. 2024(128),83-104. http://doi.org/10.1016/bs.aambs.2024.05.002.
5. Caihong Weng, Ruohao Tang, Xiaowei Peng, Yejun Han*. Co-conversion of lignocellulose-derived glucose, xylose, and aromatics to polyhydroxybutyrate by metabolically engineered Cupriavidus necator. Bioresource Technology, 2023(374): doi: 10.1016/j.biortech.2023.128762.
6. Haiqian Yang, Xiaojing Jia, Yejun Han*. Microbial redox coenzyme engineering and applications in biosynthesis. Trends in Microbiology. 2022, 30(4), http://doi.org/10.1016/j.tim.2022.01.012.
7. Ruohao Tang#, Xiaowei Peng#, Caihong Weng, Yejun Han*. The over-expression of phasin and regulator genes promoting the synthesis of polyhydroxybutyrate in Cupriavidus necator H16 under non-stress conditions. Applied and Environmental Microbiology. 2022, 88(2), http://doi.org/10.1128/AEM.01458-21.
8. Caihong Weng, Xiaowei Peng, Yejun Han*. Depolymerization and conversion of lignin to value-added bioproducts by microbial and enzymatic catalysis. Biotechnology for Biofuels and Bioproducts. 2021. 14:84, http://doi.org/10.1186/s13068-021-01934-w.
9. Ruohao Tang, Caihong Weng, Xiaowei Peng*, Yejun Han*. Metabolic engineering of Cupriavidus necator H16 for improved chemoautotrophic growth and PHB production under oxygen-limiting conditions. Metabolic Engineering. 2020. 61:11-23.
10. Xiaowei Peng, Robert Kelly, Yejun Han*. Sequential processing with fermentative Caldicellulosiruptor kronotskyensis and chemolithoautotrophic Cupriavidus necator for converting rice straw and CO2 to polyhydroxybutyrate. Biotechnology and Bioengineering. 2018. 10.1002/bit.26578.
